AgrA inhibitor F19 ( —— )

产品货号. M12157 CAS No. 1532534-68-1

COA

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MSDS

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产品名称

AgrA inhibitor F19
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens.
产品描述

AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription; binds to C-terminal DNA-binding domain (AgrA_C) from Staphylococcus epidermidis with an affinity of 2.7 uM, potentiates β-lactam antibiotics in a MRSA wound model.
同义词

——
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

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1. Greenberg M, et al. Sci Rep. 2018 Oct 1;8(1):14578.
2. Khodaverdian V, et al. Antimicrob Agents Chemother. 2013 Aug;57(8):3645-52.

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